发明名称 |
Reduction of the content of protein contaminants in compositions comprising a Vitamin K-dependent protein of interest |
摘要 |
<p>The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.</p> |
申请公布号 |
AU2005318106(B2) |
申请公布日期 |
2011.11.03 |
申请号 |
AU20050318106 |
申请日期 |
2005.12.23 |
申请人 |
NOVO NORDISK HEALTH CARE AG |
发明人 |
RASMUSSEN, DANIEL E.;HANSEN, THOMAS BUDDE;STABY, ARNE;BANG, SUSANNE;BOGSNES, ARE;AHMADIAN, HALEH;KRARUP, JANUS;ARENTSEN, ANNE CHARLOTTE |
分类号 |
C07K1/16;C07K14/745 |
主分类号 |
C07K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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