发明名称 |
NURR-1 Interacting Protein (NuIP) |
摘要 |
Provided herein are methods of promoting the activity of Nurr1 in a cell comprising contacting the cell with NuIP or an analog or fragment thereof. Also provided are methods of treating or preventing a condition associated with reduced dopaminergic function in a subject, comprising administering to the subject NuIP or an analog or fragment thereof. Methods of inhibiting the activity of Nurr1 in a cell comprising contacting the cell with a NuIP inhibitor are provided. Methods of screening for agents that modulate the interaction of Nurr1 and NuIP are also provided.
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申请公布号 |
US2011268748(A1) |
申请公布日期 |
2011.11.03 |
申请号 |
US200913063143 |
申请日期 |
2009.09.09 |
申请人 |
THE UNIVERSITY OF ROCHESTER |
发明人 |
FEDEROFF HOWARD J. |
分类号 |
A61K39/395;A61K31/713;A61K38/10;A61P25/00;A61P25/16;C07H21/04;C07K7/08;C07K16/18;C12N5/071;C12N5/0793;C12Q1/02;C12Q1/68;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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