Disclosed is a cationic lipid which is represented by formula (I) and makes it easier to introduce a nucleic acid into a cell. (In formula (I), R1 and R2 may be the same or different and each represents an alkenyl group or the like; X1 and X2 each represents a hydrogen atom, or alternatively X1 and X2 combine together to form a single bond or an alkylene group; X3 is absent or represents an alkyl group or the like; Y is absent or represents an anion; a and b may be the same or different and each represents a number of 0-3; L3 represents a single bond or the like; R3 represents an alkyl group or the like; and L1 and L2 each represents -O-, -CO-O- or -O-CO-.) Also disclosed are: a composition that contains the cationic lipid and a nucleic acid; and a method for introducing a nucleic acid into a cell, using the composition that contains the cationic lipid and a nucleic acid.
申请公布号
WO2011136368(A1)
申请公布日期
2011.11.03
申请号
WO2011JP60458
申请日期
2011.04.28
申请人
KYOWA HAKKO KIRIN CO., LTD.;KUBOYAMA, TAKESHI;ERA, TOMOHIRO;NAOI, TOMOYUKI