| 发明名称 |
Oligomer-Protease Inhibitor Conjugates |
| 摘要 |
The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
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| 申请公布号 |
US2011269677(A1) |
申请公布日期 |
2011.11.03 |
| 申请号 |
US20080530363 |
申请日期 |
2008.03.12 |
| 申请人 |
NEKTAR THERAPEUTICS |
发明人 |
RIGGS-SAUTHIER JENNIFER;CHENG LIN;VIEGAS TACEY X.;GU XUYUAN;DUARTE FRANCO J.;ZHANG WEN |
| 分类号 |
A61K38/05;A61K31/427;A61K31/4418;A61K31/4433;A61K31/472;A61K31/496;A61K31/513;A61K31/635;A61K31/665;A61P31/18;C07D213/56;C07D217/26;C07D239/10;C07D307/20;C07D401/06;C07D401/12;C07D405/12;C07D417/12;C07D493/04;C07F9/655 |
主分类号 |
A61K38/05 |
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