发明名称 |
2'-F MODIFIED RNA INTERFERENCE AGENTS |
摘要 |
This invention relates to a method of modulating the expression of a target gene in an organism comprising administering an iRNA agent, wherein the iRNA comprises at least one 2′-deoxy-2′-fluoro (2′-F) nucleotide in the antisense strand and at least one modified nucleotide in the sense strand. The invention also relates to compositions comprising a single-stranded oligonucleotide that contains at least one 2′-deoxy-2′-fluoro (2′-F) nucleotide. siRNA molecule containing these oligonucleotides have decreased immunogenicity.
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申请公布号 |
US2011269814(A1) |
申请公布日期 |
2011.11.03 |
申请号 |
US20090935083 |
申请日期 |
2009.03.26 |
申请人 |
ALNYLAM PHARAMACEUTICALS, INC. |
发明人 |
MANOHARAN MUTHIAH;RAJEEV KALLANTHOTTATHIL G. |
分类号 |
A61K31/713;C07H1/00;C07H21/02;C07K2/00;C07K9/00;C07K16/18;C12N5/071;C12N15/11 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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