Receptor (SSTR2)-selective somatostatin antagonists

摘要

This invention is directed to peptides related to somatostatin and to methods for pharmaceutical treatment of mammals using such peptides. More specifically, the invention relates to shortened receptor-selective somatostatin peptide antagonists and the inclusion of amino acid substitutions and/or additions in such peptides that confer receptor-selectivity thereto, to pharmaceutical compositions containing such peptides, to such peptides complexed with or conjugated to radioactive nuclides, to methods of diagnostic and therapeutic treatment of neoplastic and non-neoplastic mammalian diseases using such peptides, particularly peptides that are coupled to chelators or otherwise labeled, and also to methods for screening for more effective drugs using such peptides.