发明名称 |
HUMAN ANTIBODIES SPECIFIC FOR INTERLEUKIN 15 (IL-15) |
摘要 |
<p>Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.</p> |
申请公布号 |
EP1425389(B1) |
申请公布日期 |
2011.11.02 |
申请号 |
EP20020796411 |
申请日期 |
2002.08.23 |
申请人 |
GENMAB A/S |
发明人 |
VAN DE WINKEL, JAN, G., J.;VAN DIJK, MARCUS, ANTONIUS;SCHUURMAN, JANINE;GERRITSEN, ARNOUT, F.;BAADSGAARD, OLE |
分类号 |
A01K67/027;A61K39/395;A61K39/44;A61K45/00;A61P1/04;A61P17/06;A61P19/02;A61P29/00;A61P31/00;A61P35/00;A61P37/02;A61P37/06;C07K14/47;C07K16/24;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/12;C12N5/16;C12N5/18;C12N15/09;C12N15/12;C12N15/63;C12N15/64;C12P21/08;G01N33/53;G01N33/543 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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