| 摘要 |
<p>A pharmaceutical intermediate comprises aliskiren base and substrate. The aliskiren base is present as a solid dispersion. Independent claims are included for: (1) preparation of the intermediate containing aliskiren and substrate, comprising dissolving aliskiren base in a solvent or mixture of solvents and contacting the solution with a substrate, removing the solvent or mixture of solvents, and optionally granulating the obtained mixture; (2) a pharmaceutical formulation containing aliskiren base in the form of an intermediate, and optionally pharmaceutical excipient(s); and (3) a tablet containing aliskiren base (50-500 mg) and having hardness of 50-250 N, friability of less than 5% and content uniformity of 95-105%. ACTIVITY : Hypotensive; Cardiant. No biological data given. MECHANISM OF ACTION : None given.</p> |
