发明名称 POLYMORPHIC FORM OF 5-CHLORO-N-{Ý(5S)-2-OXO-3-Ý4-(3-OXOMORPHOLIN-4-YL)PHENYL¨OXA-ZOLIDIN-5-YL¨-METHYL}THIOPHENE-2-CARBOXAMIDE
摘要 <p>A polymorphic form of rivaroxaban, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxa-zolidin-5-yl]-methyl}thiophene-2-carboxamide (termed form APO-A), processes for the preparation thereof, and compositions and formulations comprising form APO-A are provided. Also provided are compositions comprising a crystalline form of rivaroxaban and solvents selected from C3 to C6 ketones, C3 to C4 amides and mixtures thereof.</p>
申请公布号 EP2382209(A1) 申请公布日期 2011.11.02
申请号 EP20090835935 申请日期 2009.12.31
申请人 APOTEX PHARMACHEM INC. 发明人 BODHURI, PRABHUDAS;WEERATUNGA, GAMINI
分类号 C07D413/14;A61K31/5377 主分类号 C07D413/14
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