PARTIAL AND FULL AGONISTS OF A1 ADENOSINE RECEPTORS

摘要

Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. In one aspect, the invention relates to a compound of formula I: (see formula I) or a pharmaceutically acceptable salt thereof, wherein: R1 is cyclopentyl or cyclohexyl, either of which may be optionally substituted with hydroxy or -CO2CH2CH3; R2 is hydrogen; R3 is phenyl, isoxazolyl, thiophenyl, or thiazolyl, any of which may be optionally substituted with one or more substituents selected from methyl, methoxy, fluoro, and chloro; R4 and R5 are hydrogen; T is a covalent bond or methylene; X is a covalent bond; Y is -O-, -S-, -NH-, or a covalent bond; and Z is methylene or ethylene.