发明名称 |
DELAYED RELEASE, ORAL DOSAGE COMPOSITIONS THAT CONTAIN AMORPHOUS CDDO-ME |
摘要 |
<p>Pharmaceutical formulations exhibit a desirably low Cmax, among other properties, that contain particles of amorphous bardoxolone methyl, either in pure form or in the form of a solid dispersion, admixed with particles of a hydrophilic binding agent. Such formulations possess the advantage of higher oral bioavailability, relative to formulations based on the crystalline form of bardoxolone methyl.</p> |
申请公布号 |
KR20110118721(A) |
申请公布日期 |
2011.10.31 |
申请号 |
KR20117021250 |
申请日期 |
2010.02.12 |
申请人 |
REATA PHARMACEUTICALS, INC. |
发明人 |
ZHANG JIANG;MEYER COLIN J. |
分类号 |
A61K9/16;A61K9/22;A61K47/38;A61K47/48 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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