ORAL DOSAGE FORM COMPRISING INTERDISPERSED (I) AN OPIOID AGONIST AND (II) AN ORALLY BIOAVAILABLE OPIOID ANTAGONIST IN A NON-RELEASABLE FORM

摘要

Disclosed is an opioid antagonist composition and an oral dosage form comprising an opioid antagonist particle in a coating which is insoluble in the gastrointestinal system or
an opioid antagonist dispersed in a matrix that renders the antagonist substantially non-releasable or
an opioid antagonist dispersed in a melt-extruded matrix.