摘要 |
<p>METHOD FOR PRODUCING A RADIOPHARMACEUTICAL AbstractThe invention relates to a method for producing a radiopharmaceutical. In said method, steps (A), (B), and (C) are performed. In a step (A), an H-Li exchange is made by adding an alkyllithium to an isocyanide, wherein the a-H atom of the isocyanide is replaced with an Li atom. In a step (B), 11CO2 is added and bonded to the a-C atom of the isocyanide. By means of a two-stage hydrolysis in step (C), the Li atom is replaced with an H atom and an amino group is formed from the isocyanide group, for example, by adding NH4CI and HI. According to the invention, the reaction is continuously performed in particular in a microfluidic structure so that reaction times of less than 300 seconds can be achieved for the partial steps (A, B). Because the produced radiopharmaceutical has only a low half-life, the short production time has a positive effect on the yield of radioactive pharmaceutical.FIG. 2</p> |
申请人 |
SIEMENS AKTIENGESELLSCHAFT |
发明人 |
KINZL, MARKUS;LADE, OLIVER;SCHULTZ, CHRISTIAN P.;STECKENBORN, ARNO;THALMANN, FRANK |