| 发明名称 |
ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHEMOSENSITIZERS |
| 摘要 |
<p>Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.</p> |
| 申请公布号 |
SI1379510(T1) |
申请公布日期 |
2011.10.28 |
| 申请号 |
SI20020030957T |
申请日期 |
2002.03.01 |
| 申请人 |
ICOS CORPORATION |
发明人 |
KEEGAN KATHLEEN S.;KESICKI EDWARD A.;GAUDINO JOHN JOSEPH;COOK ADAM WADE;COWEN SCOTT DOUGLAS;BURGESS LAURENCE EDWARD |
| 分类号 |
A61K31/4965;A61K31/497;A61K31/498;A61K31/5377;A61K45/06;A61P35/00;A61P43/00;C07D213/30;C07D213/40;C07D213/75;C07D213/77;C07D215/34;C07D231/40;C07D239/42;C07D239/46;C07D241/12;C07D241/20;C07D241/30;C07D241/44;C07D241/54;C07D251/22;C07D253/06;C07D253/07;C07D257/06;C07D277/48;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D453/02;C07D521/00 |
主分类号 |
A61K31/4965 |
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