| 摘要 |
The present invention relates to a novel siRNA structure and to the use thereof, and more particularly, to a siRNA molecule and to a target gene silencing method using same, wherein the siRNA molecule is a double-stranded siRNA molecule comprising an antisense strand and a sense strand, and at least one or more single nucleotide bulges induced by the introduction of single nucleotides are present on the antisense strand of the siRNA, specifically at the second position of the 5' end. The present invention provides a siRNA molecule having a novel structure, which exhibits superior efficiency of target gene silencing, minimizes off-target effects caused by antisense strands, and thus has improved target selectivity. Therefore, the siRNA molecule of the present invention can be widely used in siRNA-based gene silencing technologies such as a gene therapy or the like in lieu of conventional siRNA molecules. |
