发明名称 |
TARGETED AND LIGHT-ACTIVATED CYTOSOLIC DRUG DELIVERY |
摘要 |
The present invention provides methods and compositions for highly precise spatial and temporal control over cytosolic delivery of compounds, in particular, those compounds that would otherwise be cell-impermeable. Among other things, the present invention provides a composition for targeted drug delivery comprising a nanoparticle, a targeting moiety specific for a cell type of interest, a light-activated drug delivery system, wherein the nanoparticles are associated with the targeting moiety and the light-activated drug delivery system. |
申请公布号 |
WO2011133925(A2) |
申请公布日期 |
2011.10.27 |
申请号 |
WO2011US33655 |
申请日期 |
2011.04.22 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CHILDREN'S HOSPITAL BOSTON;FEBVAY, SEBASTIEN;MARINI, DAVIDE, MAURIZIO;CLAPHAM, DAVID, E. |
发明人 |
FEBVAY, SEBASTIEN;MARINI, DAVIDE, MAURIZIO;CLAPHAM, DAVID, E. |
分类号 |
A61K9/14;A61K9/16;A61K39/395;A61K47/02;A61K47/48;A61K49/00;A61P35/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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