RTK-BPB SPECIFICALLY BINDING TO RTK

摘要

The present invention relates to a cytokine-bipodal peptide binder specifically binding to cytokine, comprising (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a cytokine-target binding region I and a cytokine-target binding region II which bind to both ends of the structure stabilizing region and comprise n and m amino acids randomly selected, respectively. The cytokine-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to cytokine, thereby showing very high affinity to a cytokine target. The cytokine-bipodal peptide binder of the present invention has medical use, can be used for in vivo molecular imaging and targeting for drug delivery, and is very useful as an escort molecule.