发明名称 |
TMEM195 ENCODES FOR TETRAHYDROBIOPTERIN-DEPENDENT ALKYLGLYCEROL MONOOXYGENASE ACTIVITY |
摘要 |
The present invention relates to the provision of a pharmaceutical composition comprising a nucleic acid molecule encoding a alkylglycerol monooxygenase (TMEM195; glyceryl ether monooxygenase; EC 1.14.16.5). The present invention also provides for a method for producing said alkylglycerol monooxygenase (TMEM195; glyceryl ether monooxygenase; EC 1.14.16.5) polypeptides encoded by said polynucleotides. Moreover, the use of such polypeptides as well as of antagonists/inhibitors of such polypeptides in a medical setting (e.g. in from of a pharmaceutical composition) and methods for assessing the activity of a candidate molecule suspected of being an antagonist/inhibitor or agonist/activator in order to identify potential antagonists/inhibitors or agonists/activators of the polypeptide are also provided in the present invention. Finally, the present invention provides kits for carrying out said methods wherein the kits comprise polynucleotides and/or antibodies capable of detecting the activity of alkylglycerol monooxygenase. |
申请公布号 |
WO2011131626(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
WO2011EP56142 |
申请日期 |
2011.04.18 |
申请人 |
MEDIZINISCHE UNIVERSITAET INNSBRUCK;WERNER, ERNST R.;WATSCHINGER, KATRIN |
发明人 |
WERNER, ERNST R. |
分类号 |
C12N9/02;A61K38/17;A61K38/44 |
主分类号 |
C12N9/02 |
代理机构 |
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主权项 |
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地址 |
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