发明名称 |
COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF |
摘要 |
The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.
|
申请公布号 |
CA2795222(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
CA20102795222 |
申请日期 |
2010.04.21 |
申请人 |
SIGNATURE THERAPEUTICS, INC. |
发明人 |
JENKINS, THOMAS E.;HUSFELD, CRAIG O.;SEROOGY, JULIE D.;WRAY, JONATHAN W. |
分类号 |
A61K31/485;A61K38/43;A61P25/04;G01N33/15 |
主分类号 |
A61K31/485 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|