发明名称 |
MUTANT STRAINS OF ESCHERICHIA COLI, A METHOD OF TESTING POTENTIAL ANTIBACTERIAL AGENTS USING SAID STRAINS AS WELL AS A TESTING KIT |
摘要 |
<p>The subject of the present invention are mutant strains of Escherichia coli MG6165 (ATCC nr 47076) lacking all potassium transporters: Kdp, Kup and Trk (?Ktrans), encompassing strains lacking at least one of the genes encoding mechanically gated channels mscS and mscL (?Ktrans ?mscS i/lub ?mscL). In particular, it concerns Escherichia coli MG61655 (ATCC No. 47076) lacking all potassium transporters: Kdp, Kup and Trk (?Ktrans), which additionally are devoid of the mechanically gated channel gene mscS - E. coli (?Ktrans ?mscS), the mechanically gated channel gene mscL - E. coli (?Ktrans ?mscL) and/or both the mechanically gated channel genes mscS and mscL - E. coli (?Ktrans ?mscS ?mscL). The subject of the present invention is also a method of testing chemical compounds for potential antibacterial properties, making use of the abovementioned strains. Another subject of the present invention is a kit for testing chemical compounds as potential antibacterial substances, containing the abovementioned strains.</p> |
申请公布号 |
CA2796861(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
CA20112796861 |
申请日期 |
2011.04.23 |
申请人 |
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGOPAN |
发明人 |
KOPROWSKI, PIOTR;KUBALSKI, ANDRZEJ;GRAJKOWSKI, WOJCIECH |
分类号 |
C12N1/20;C07K14/245;C12Q1/18 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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地址 |
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