发明名称 |
MUTEINS OF HNGAL AND RELATED PROTEINS WITH AFFINITY FOR A GIVEN TARGET |
摘要 |
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
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申请公布号 |
US2011262353(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
US20090737240 |
申请日期 |
2009.06.24 |
申请人 |
TECHNISCHE UNIVERSITAT MUNCHEN |
发明人 |
SKERRA ARNE;EICHINGER ANDREAS;KIM HYUN-JIN |
分类号 |
A61K51/08;A61K49/00;A61P35/00;C07K1/00;C07K14/47;C07K16/00;C07K17/10;C12N1/21;C12N9/96;C12N15/12;C12N15/63;C12P21/02 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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