发明名称 |
B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING |
摘要 |
Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl3.6H2O to oxidize the D ring and separating the resulting organic layer and drying.
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申请公布号 |
US2011264027(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
US20090918238 |
申请日期 |
2009.02.19 |
申请人 |
HEALTH RESEARCH, INC. |
发明人 |
PANDEY RAVINDRA K.;LIU CHAO;DOBHAL MAHABEER;POTTER WILLIAM;MORGAN JANET;OSEROFF ALLAN;PINCUS STEPHANIE |
分类号 |
A61N5/00;A61K49/00;A61K49/04;A61K51/04;A61P35/00;C07D487/22 |
主分类号 |
A61N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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