NANOPARTICLES FOR TUMOR-TARGETING AND PROCESSES FOR THE PREPARATION THEREOF

摘要

The present invention provides a pharmaceutical composition for tumor-targeting in the form of a nano-dispersion comprising nanoparticles having a mean particle size of 10 to 1,000 nm in an aqueous medium, wherein the nanoparticles comprise a therapeutically effective amount of an anticancer agent; a divalent or trivalent transition metal ion or alkali earth metal ion; and an oil, and wherein hyaluronic acid or its salt is bound on a surface of the nanoparticles. And also, the present invention provides nanoparticles for tumor-targeting obtained by drying the pharmaceutical composition in the form of a nano-dispersion. And also, the present invention provides a process for preparing the pharmaceutical composition in the form of a nano-dispersion and a process for preparing the nanoparticles.