MODULATION OF GLUCOSYLCERAMIDE SYNTHASE (GCS) EXPRESSION

摘要

Provided herein are methods, compounds, and compositions for reducing expression of glucosylceramide synthase (GCS) mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preventing or decreasing airway inflammation and/or airway hyperresponsiveness in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of airway inflammation or airway hyperresponsiveness, or a symptom thereof.