MUTANT LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN WITH INCREASED BINDING TO ALZHEIMER AMYLOID-BETA PEPTIDE

摘要

A mutant low-density lipoprotein receptor related protein-1 binds to Alzheimer amyloid-beta (Aß) peptide with greater affinity compared to its wild- type homolog. This binding may be used to detect Aß or to separate Aß from the rest of a subject's body. In Alzheimer disease, it may be used to provide diagnostic results by detecting Aß, treatment by removing Aß, or both.