The invention provides a replication competent adenovirus, being capable of replicating and having lytic capacity in a host cell, the virus genome comprising at least one DNA sequence coding for a silencing factor functional in reducing expression and/or activity of a target gene in the host cell. The invention further provides a kit of parts comprising a silencing factor and a replication competent adenovirus and a cell comprising a silencing factor and a replication competent adenovirus. In addition, the invention provides use of the kit of parts and the cell according to the invention.
