| 发明名称 |
ANTI-IL-12/IL-23 ANTIBODIES |
| 摘要 |
The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12Rβ2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rβ1.
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| 申请公布号 |
US2011262445(A1) |
申请公布日期 |
2011.10.27 |
| 申请号 |
US200913058914 |
申请日期 |
2009.08.14 |
| 申请人 |
CEPHALON AUSTRALIA PTY LTD. |
发明人 |
CLARKE ADAM WILLIAM;DOYLE ANTHONY GERARD;JENNINGS PHILIP;POULTON LYNN DOROTHY;WAI BERNADETTE;POW ANDREW JAMES |
| 分类号 |
A61K39/395;A61P3/00;A61P3/08;A61P9/00;A61P9/10;A61P11/00;A61P17/06;A61P17/14;A61P19/02;A61P19/08;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P37/08;C07H21/00;C07H21/04;C07K1/107;C07K1/14;C07K16/24;C12P21/02 |
主分类号 |
A61K39/395 |
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