发明名称 |
Maleamic Acid Polymer Derivatives and Their Bioconjugates |
摘要 |
The present invention is directed a method comprising administering a composition to an individual, wherein the composition comprises a plurality of conjugates, each conjugate in the plurality a protein derivatized with a water-soluble polymer, wherein the polymer is coupled to the protein via succinimide groups covalently attached to either cysteine sulfhydryl groups or lysine amino groups, and substantially all of the succinimide groups present in the composition are present in a ring-opened form.
|
申请公布号 |
US2011262379(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
US201113172043 |
申请日期 |
2011.06.29 |
申请人 |
NEKTAR THERAPEUTICS |
发明人 |
KOZLOWSKI ANTONI;GROSS, III REMY F.;MCMANUS SAMUEL P. |
分类号 |
A61K38/16;A61K47/48;A61P3/04;A61P7/02;A61P9/00;A61P9/12;A61P11/00;A61P25/00;A61P29/00;A61P31/00;A61P35/00;C08G65/329;C08G65/333 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|