发明名称 |
PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES |
摘要 |
<p>The invention relates to a process for the preparation of the compound of formula (I), which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula (X), reacting the halobenzyne of formula X so formed with cyclopentadiene to (III), b) reacting III in the presence of an inert solvent with an oxidant to (IV), c) reacing IV in the presence of a Lewis acid and a hydride source to (V), d) reacting V in the presence of an oxidizing agent, a base and an inert solvent to (VI), e) converting VI in the presence of a phosphane and CCl4 or CHCl3 to (VII), and either f1) reacting VII with NH3 in the presence of a catalyst to the compound of formula (VIII); and g) reacting VIII in the presence of a base with a compound of formula (IX), to the compound of formula (I); or f2) reacting the compound of formula (VII), in the presence of a solvent, a base, a copper catalyst and at least one ligand with the compound of formula (IXa), to the compound of formula (I).</p> |
申请公布号 |
WO2011131545(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
WO2011EP55871 |
申请日期 |
2011.04.14 |
申请人 |
SYNGENTA PARTICIPATIONS AG;DUMEUNIER, RAPHAEL;SCHLETH, FLORIAN;VETTIGER, THOMAS;ROMMEL, MICHAEL;TRAH, STEPHAN |
发明人 |
DUMEUNIER, RAPHAEL;SCHLETH, FLORIAN;VETTIGER, THOMAS;ROMMEL, MICHAEL;TRAH, STEPHAN |
分类号 |
C07D231/14;C07C25/24;C07C35/52;C07D303/17 |
主分类号 |
C07D231/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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