| 摘要 |
<p>Methods and systems for processing polynucleotides (e.g., DNA) are disclosed, A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can he used to, for example, concentrate polynucleotides of a sample and/or separate inhititors of amplification reactions from the polynucleotides Microfluidic devices with a processing region are disclosed.
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