MICRO-RNA SCAFFOLDS AND NON-NATURALLY OCCURRING MICRO-RNAS
摘要
The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
申请公布号
EP2160477(A4)
申请公布日期
2011.10.26
申请号
EP20080769579
申请日期
2008.05.22
申请人
DHARMACON, INC.
发明人
KELLEY, MELISSA;BIRMINGHAM, AMANDA;KARPILOW, JON;KHVOROVA, ANASTASIA;SULLIVAN, KEVIN