发明名称 |
PROTEIN SUBSTANCE HAVING TRIPLE HELIX STRUCTURE AND MANUFACTURING METHOD THEREFOR |
摘要 |
<p>As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities.</p> |
申请公布号 |
EP2380979(A1) |
申请公布日期 |
2011.10.26 |
申请号 |
EP20090834882 |
申请日期 |
2009.12.22 |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;FUSO PHARMACEUTICAL INDUSTRIES, INC. |
发明人 |
SUZUKI, YUSUKE;TAHARA, HIROSHI;YAMAMOTO, KEIICHI;KITAHARA, YUZURU;SUZUKI, YASUHIKO |
分类号 |
C12N15/09;C07K14/78;C07K19/00;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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