Autoimmune and inflammatory disorder therapy

摘要

Compounds that bind to phosphatidylinositol-4-kinase IIIβ(PI4KIIIβ) and inhibit the binding of PI4KIIIβto its substrate and/or inhibit PI4KIIIβactivity may be used in the treatment and/or prevention of an autoimmune or inflammatory disorder, or organ or cell transplant rejection. A new assay for identifying compounds for use in treating and/or preventing those pathological conditions, which comprises measuring the inhibition of PI4KIIIβactivity, is also disclosed.