| 发明名称 |
Infection and treatment of neoplasms with vesicular stomatitis virus |
| 摘要 |
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
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| 申请公布号 |
US8043612(B2) |
申请公布日期 |
2011.10.25 |
| 申请号 |
US20080292377 |
申请日期 |
2008.11.18 |
| 申请人 |
WELLSTAT BIOLOGICS CORPORATION |
发明人 |
ROBERTS MICHAEL S.;LORENCE ROBERT M.;GROENE WILLIAM S.;RABIN HARVEY;VON BORSTEL REID W. |
| 分类号 |
A01N63/02;A61K45/00;A61K31/282;A61K31/573;A61K35/76;A61K38/00;A61K38/19;A61K38/20;A61K38/21;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07J5/00;C07K16/24;C12N7/01;C12N7/02;C12N15/00;G01N33/50 |
主分类号 |
A01N63/02 |
| 代理机构 |
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