发明名称 |
Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering |
摘要 |
Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or more of the gene products of the cluster are provided for heterologous production of capreomycin and capreomycin derivatives.
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申请公布号 |
US8044186(B2) |
申请公布日期 |
2011.10.25 |
申请号 |
US20080118362 |
申请日期 |
2008.05.09 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
THOMAS MICHAEL GEORGE;FELNAGLE ELIZABETH ANNE;RONDON MICHELLE RENEE;BERTI ANDREW DAVID |
分类号 |
C07H21/02;C12N1/12;C12P19/62 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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