发明名称 |
METHOD AND COMPOSITION FOR DIAGNOSING CARCINOMA |
摘要 |
PROBLEM TO BE SOLVED: To provide a method of screening for the presence of a malignant condition using antibodies specific for mesothelin/MPF and/or mesothelin/MPF-related antigens to detect polypeptides that naturally occur in soluble form.SOLUTION: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular, the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides the method of screening for the presence of a malignant condition in a subject by detecting reactivity of the antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages. |
申请公布号 |
JP2011206062(A) |
申请公布日期 |
2011.10.20 |
申请号 |
JP20110162531 |
申请日期 |
2011.07.25 |
申请人 |
PACIFIC NORTHWEST RESEARCH INST |
发明人 |
SCHOLLER NATHALIE B;HELLSTROM INGEGERD;HELLSTROM KARL ERIK |
分类号 |
C12N15/09;C07K14/47;C07K16/28;C07K16/30;C07K19/00;C12N15/113;C12P21/02;C12P21/08;C12Q1/68;G01N33/53;G01N33/533;G01N33/534;G01N33/535;G01N33/574;G01N33/577 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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