发明名称 |
OLIGONUCLEOTIDES WHICH INHIBIT P53 INDUCTION IN RESPONSE TO CELLULAR STRESS |
摘要 |
The present invention relates to novel oligonucleotides which comprise p53 5'-UTR sequence TCCCTGG (SEQ ID NO: 1) or the complementary p53 3'-UTR sequence CCAGGGA (SEQ ID NO: 2) and their use for such therapeutic applications as protection of normal tissues from the toxicities of chemical or radiation exposure; reducing tissue damage in hypoxia-reperfusion injury, neurodegenerative disorders, oxidative stress, injuries, hyperthermia; preventing aging; preservation of tissues and organs prior to transplanting, etc. |
申请公布号 |
WO2011094546(A3) |
申请公布日期 |
2011.10.20 |
申请号 |
WO2011US22930 |
申请日期 |
2011.01.28 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;KASTAN, MICHAEL, B.;CHEN, JING |
发明人 |
KASTAN, MICHAEL, B.;CHEN, JING |
分类号 |
C07H21/00;A61K31/7088;C12N15/113 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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