发明名称 |
ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE, AND/OR FEVER |
摘要 |
The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved. |
申请公布号 |
WO2011066374(A3) |
申请公布日期 |
2011.10.20 |
申请号 |
WO2010US57986 |
申请日期 |
2010.11.24 |
申请人 |
ALDER BIOPHARMACEUTICALS, INC.;SMITH, JEFFREY T.L.;LATHAM, JOHN;LITTON, MARK;SCHATZMAN, RANDALL |
发明人 |
SMITH, JEFFREY T.L.;LATHAM, JOHN;LITTON, MARK;SCHATZMAN, RANDALL |
分类号 |
A61K39/395;A61K38/16;A61P25/00;A61P29/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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