发明名称 |
Methods |
摘要 |
A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the binding of the LRRK2 to a 14-3-3 polypeptide. The method is considered to be useful in assessing the effect of putative LRRK2 inhibitors in cell based systems, including in vivo systems.
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申请公布号 |
US2011256553(A1) |
申请公布日期 |
2011.10.20 |
申请号 |
US20100763005 |
申请日期 |
2010.04.19 |
申请人 |
NICHOLS R JEREMY;ALESSI DARIO;DZAMKO NICOLAS |
发明人 |
NICHOLS R. JEREMY;ALESSI DARIO;DZAMKO NICOLAS |
分类号 |
G01N33/53;C07K16/00;C12Q1/48 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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