INDUCED PLURIPOTENT STEM CELLS AND USES THEREOF

摘要

This invention generally relates to disease-specific pluripotent stem cells that are derived from somatic cells that carry a mutation in the PTPNl 1 gene. The stem cells are capable of differentiating into cells or tissues affected by the PTPNl 1 mutation. The stem cells and differentiated cells can be used to study various diseases that are associated with mutations in the PTPNl 1 gene, and to identify novel therapeutic agents for diagnosis and treatment of diseases that are associated with mutations in PTPNl 1.