| 摘要 |
PROBLEM TO BE SOLVED: To provide an immunogenic preparation and a vaccine, comprising, on the one hand, a plasmid encoding and expressing a gene from PCV, in particular selected from the group consisting of ORF1 of PCV-2, ORF2 of PCV-2, ORF1 of PCV-1 and ORF2 of PCV-1, and, on the other hand, an element of increasing the immune response.SOLUTION: The element can be a carbomer, a porcine cytokine, e.g. GM-CSF or a cationic lipid of formula (I) responding to the expression product of the gene (wherein Ris 12-18C saturated or unsaturated linear chain aliphatic; Ris 2-3C another aliphatic; and X is a hydroxy or amine group). The cationic lipid can be DMRIE, possibly coupled with DOPE. |
