发明名称 |
Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics |
摘要 |
Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.
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申请公布号 |
US2011257211(A1) |
申请公布日期 |
2011.10.20 |
申请号 |
US20100975631 |
申请日期 |
2010.12.22 |
申请人 |
ADVANCED CANCER THERAPEUTICS, LLC;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. |
发明人 |
CHAND POORAN;CHESNEY JASON A.;CLEM BRIAN F.;TAPOLSKY GILLES H.;TELANG SUCHETA;TRENT JOHN O. |
分类号 |
A61K31/506;A61K31/4196;A61K31/427;A61K31/428;A61K31/4439;A61K31/454;A61K31/4709;A61P35/00;C07D249/12;C07D401/04;C07D401/12;C07D403/12;C07D417/12;C12N9/99 |
主分类号 |
A61K31/506 |
代理机构 |
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地址 |
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