摘要 |
<p>The current application relates to a process for preparing O3-(butanoyloxymethyl)-O5-methyl-4-(2, 3-dichlorophenyl)-2,6-dimethyl-1,4- dihydropyridme-3,5-dicarboxylate, clevidipine butyrate, by alkylation of 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5- methoxycarbonyl-3-pyridinecarboxylic acid with tetramethylammonium hydroxide and chloromethyl butyrate in a dioxane/water solvent. The final product is purified by crystallization in a mixed solvent system of dichloromethane/heptane or lsopropanol/water.</p> |