发明名称 |
TRUNCATED DANCE, DANCE COMPLEX AND METHOD OF USING THESE |
摘要 |
<p>The present invention provides a screening method that enables the development of a pharmaceutical of a new mechanism of action allowing the regulation of the formation of elastic fibers, and various means necessary for the method. More specifically, the present invention provides a polypeptide obtained by cleaving DANCE and a polynucleotide that encodes the same; a method of cleaving DANCE; an antibody against a polypeptide obtained by cleaving DANCE; a method of measuring the amount of DANCE cleaved and a kit therefor; a DANCE mutant and a polynucleotide that encodes the same; various DANCE complexes and methods of preparing the same; a screening method for a substance capable of regulating the activity of DANCE or a DANCE-specific protease, and the substance obtained thereby; a regulator of the formation of elastic fibers; and a kit comprising at least DANCE and a polynucleotide that encodes the same, and the like.</p> |
申请公布号 |
EP1762610(B1) |
申请公布日期 |
2011.10.19 |
申请号 |
EP20050720545 |
申请日期 |
2005.03.04 |
申请人 |
KANSAI MEDICAL UNIVERSITY |
发明人 |
NAKAMURA, TOMOYUKI;HIRAI, MARETOSHI |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K45/00;A61K48/00;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;A61P43/00;C07K14/47;C07K14/475;C07K16/18;C07K16/22;C12N9/64;C12P21/08;C12Q1/26;C12Q1/37;G01N33/15;G01N33/50;G01N33/53;G01N33/556;G01N33/573 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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