发明名称 |
Mutated HOXB4 proteins with improved stability, and methods of use thereof |
摘要 |
A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
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申请公布号 |
US8039436(B2) |
申请公布日期 |
2011.10.18 |
申请号 |
US20080129919 |
申请日期 |
2008.05.30 |
申请人 |
BRITISH COLUMBIA CANER AGENCY BRANCH;ADAERATA, LIMITED PARTNERSHIP;VALORISATION-RECHERCHE, LIMITED PARTNERSHIP;RSEM, LIMITED PARTNERSHIP |
发明人 |
SAUVAGEAU GUY;HUMPHRIES KEITH;ROY DENIS-CLAUDE;BESLU NATHALIE |
分类号 |
A61K38/16;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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