发明名称 |
Cytoskeletal active compounds, composition and use |
摘要 |
The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.
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申请公布号 |
US8039465(B2) |
申请公布日期 |
2011.10.18 |
申请号 |
US20100695348 |
申请日期 |
2010.01.28 |
申请人 |
INSPIRE PHARMACEUTICALS, INC. |
发明人 |
LAMPE JOHN W.;PLOURDE, JR. ROBERT;SHE JIN;VITTITOW JASON L.;WATSON PAUL S.;CRIMMINS MICHAEL T.;SLADE DAVID J. |
分类号 |
A61K31/54 |
主分类号 |
A61K31/54 |
代理机构 |
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地址 |
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