发明名称 |
TECHNISCHE HERSTELLUNG VON TIOTROPIUMBROMID |
摘要 |
Preparation of tropenol (I) involves: (a) reducing a scopine ester (II) using zinc in presence of an activating metal salt; and (b) saponifying the product using base. Preparation of tropenol of formula (I) (or its acid addition salt) involves: (a) reducing a scopine ester of formula (II) (or its acid addition salt or hydrate) using zinc in presence of an activating metal salt (preferably an iron or copper salt) in a solvent; and (b) saponifying the product using base. R = 1-4C alkyl or phenyl-(1-4C) alkyl (both optionally substituted by OH or 1-4C alkoxy). |
申请公布号 |
AT527257(T) |
申请公布日期 |
2011.10.15 |
申请号 |
AT20070101821T |
申请日期 |
2002.06.08 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
SOBOTTA, RAINER;RAPP, ARMIN |
分类号 |
C07D451/10;C07B61/00;C07D209/00;C07D221/00;C07D451/02;C07D451/06;C07D471/08 |
主分类号 |
C07D451/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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