NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

摘要

THE PRESENT INVENTION PROVIDES A COMPOUND REPRESENTED BY GENERAL FORMULA (1) BELOW OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF: WHEREIN: X IS SELECTED FROM HETEROARYL ETC., Y1 AND Y2 ARE SELECTED FROM -N= ETC., Y3 AND Y4 ARE SELECTED FROM -CH= ETC., A IS SELECTED FROM SULFAMIDE ETC., R1 IS SELECTED FROM HYDROGEN ETC., AND R2 IS SELECTED FROM CI-6 ALKYL ETC. THE COMPOUND OR SALT HAS SUFFICIENTLY HIGH ANTITUMOR ACTIVITY, AND IS USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS, PARTICULARLY CANCERS. THE PRESENT INVENTION ALSO PROVIDES A PHARMACEUTICAL COMPOSITION CONTAINING THE COMPOUND OR SALT AS AN ACTIVE INGREDIENT.