MANUFACTURING METHOD OF {2-AMINO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 3-(1-DIPHENYLMETHYLAZETIDIN-3-YL) ESTER 5-ISOPROPYL ESTER}

摘要

PROBLEM TO BE SOLVED: To provide a manufacturing method of azelnidipine hardly forming by-products.SOLUTION: The manufacturing method of {2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) ester 5-isopropyl ester} comprises causing 2-(3-nitrobenzylidene)acetoacetic acid isopropyl ester to react with 3,3-diaminoacrylic acid (1-diphenylmethylazetidin-3-yl) ester acetic acid salt in an organic solvent in a nitrogen atmosphere.