发明名称 |
ANTITUMOR VACCINATION USING ALLOGENEIC TUMOR CELLS EXPRESSING ALPHA (1,3)-GALACTOSYLTRANSFERASE |
摘要 |
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express anα(1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. Theαgalactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.
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申请公布号 |
US2011250233(A1) |
申请公布日期 |
2011.10.13 |
申请号 |
US20100878756 |
申请日期 |
2010.09.09 |
申请人 |
CENTRAL IOWA HEALTH SYSTEM |
发明人 |
LINK, JR. CHARLES J.;SEREGINA TATIANA;ROSSI GABRIELA |
分类号 |
A61K39/00;A01K67/027;A61P35/00;A61P37/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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地址 |
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